Support the gestation

Hydroxyprogesterone Caproate Injection USP is a sterile, long-acting preparation of the caproate ester of the naturally occurring progestational hormone, hydroxyprogesterone, in an oil solution for intramuscular use5,6. The chemical name for hydroxyprogesterone caproate is pregn-4-ene-3,20-dione, 17[(1-oxohexyl)oxy]. It has an empirical formula of C27H40O4 and a molecular weight of 428.60. Hydroxyprogesterone caproate exists as white to creamy white crystalline powder.


  • Hydroxyprogesterone caproate is indicated for the prevention of spontaneous preterm births in women with a singleton gestation who have previously had a spontaneous preterm birth.5,7
  • The US Food and Drug Administration has approved the use of this agent during pregnancy to reduce the risk of recurrent preterm birth in women with a history of at least 1 prior spontaneous preterm delivery.4
  • In non-pregnant women, hydroxyprogesterone caproate is indicated for:6
    • Treatment of advanced adenocarcinoma of the uterine corpus (stage III or IV)
    • Management of amenorrhea (primary and secondary)
    • Abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as submucous fibroids or uterine cancer
    • As a test for endogenous estrogen production
    • Production of secretory endometrium and desquamation.6

Dosage and Administration

  • Due to low viscosity of the vehicle, hydroxyprogesterone caproate may be administered with a small gauge needle.6
  • Care should be taken to inject it deeply into the upper outer quadrant of the gluteal muscle following the usual precautions for intramuscular injection.6
  • As 250 mg potency provides a high concentration in a small volume, special care should be taken to administer the full dose.6
  • Use of a wet needle or syringe may make the solution cloudy, however, this does not affect the potency of the material.6
  • Visual inspection of parenteral drug products should be done for particulate matter and discoloration prior to administration, whenever solution and container permit.6
  • Protect it from light.6
  • Store vial in its box.6
  • Store upright.6


  • Hydroxyprogesterone caproate is contraindicated in patients with:
    • Known or suspected carcinoma of the breast, other hormone-sensitive cancer, or history of these conditions
    • Undiagnosed abnormal vaginal bleeding
    • Liver dysfunction or disease
    • Missed abortion
    • History of hypersensitivity to the drug
    • Current or history of thrombotic or thromboembolic disorders.
  • It is also contraindicated as a diagnostic test for pregnancy.6
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