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• Rabies Vaccine I.P Human (Cell Culture)
• Purified Inactivated Rabies Vaccine prepared on Vero Cells for the prophylactic or Post-Exposure Treatment (PET)

Composition per single dose:

• Freeze-dried vaccine: One immunizing dose contains the protective activity of equal to or greater than 2.5 International Units (IU) even after exposure at 37 degree centigrade for one month.
• Rabies Virus (L.Pasteur 2061/Vero) propagated on Vero cell line, inactivated with beta-propiolactone. Thiomersol @ 0.015% added as preservative
  Maltose……………………………….q.s. per immunizing dose
  Human Serum Albumin ……………..q.s. per immunizing dose.
  Sodium Chloride (0.9%) for Injection I.P.- 0.5 ml.

The antibiotics Neomycin, Kanamycin and Polymyxin - B sulphate used in the cell and virus cultures are eliminated to the greatest extent during purification procedures and cannot be detected in the final vaccine.

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INDICATIONS:

For active immunization against rabies both for prophylaxis and post-bite therapy in all age group of humans

• For prophylactic immunization of all high-risk group of persons such as Veterinarians, Municipal workers, Medical and Paramedical personnel, Forest and zoo personnel, Hunters, Laboratory personnel working with suspected rabies materials and pet owners.
• For immunization against rabies after exposure (after contact with a rabid or suspected rabid animal)

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DOSAGE:

Prophylaxis: Three immunizing doses on 0,7 and 28 days followed by the first booster after one year and subsequently in every three years

Post exposure: Six immunizing doses on post exposure days 0,3,7,14,28 and 90 (“0” day being the day of the first vaccination).

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ADMINISTRATION:

1. Reconstitute the freeze dried vaccine with the diluent supplied in the ampoule.

2. Administer the reconstituted vaccine (entire quantity of the vial) by deep intramuscular route in the deltoid region or in small children, into the anterolateral region of the thigh muscle. The reconstituted vaccine should be used immediately and not to be stored for administration later.

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CONTRAINDICATIONS:
In principle, there are no contraindications for administering the vaccine as the high risk of death in rabies outweighs all other considerations, specially in case of post-bite therapy.

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CAUTIONS:

1. Concurrent use of immunosuppressive agents like corticosteroids shall be avoided as it may hamper in the development of protective antibodies.

2. In case of severe bites, local infiltration of the wounds with antirabies immunoglobulins is recommended.

3. Delay in the commencement of post-bite therapy, incomplete and irregular therapy can cause failure of protection.
   

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STORAGE:
To be stored at temperature between 2 and 8 degrees centigrade. Do not store the vaccine in deep freezer.

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PRESENTATION:
The vaccine is supplied as a single dose vial in a mono-carton with the diluent for reconstitution along with disposable syringe and needle.